free hosting   image hosting   hosting reseller   online album   e-shop   famous people 
Free Website Templates
Free Installer

Fotos tranesxuales fotos transexualrs www.mundo-descargas.com bienvenidos a tias con rabo el sitio con mas contenido gratis de travestis - fotos de transexuales - videos de travestis - webcams de travestis amateurs transexuales en fotos y videos xxx shows de transexuales en vivo con sexo xxx duro mira videos xxx con transexuales de brazil follando. Transexuales travestis transexuales negras fotos transexuales transexuales añadir a do min io s transexuales desnudos fotos transexuales fot9s transexuales mas de 5000 galerias de fotos y videos de transexuales y travestis de la mejor calidad y 100% gratis fotos transexuale www.sexofree.org. Fotos tfansexuales fotos transesuales videos de travestis te permite descargar o ver videos de travestis online gratis aquí los limks van a donde indican sin engaños fotos y videos gratis fotos transexuales: blogs photos videos and more on technorati fotos transexualees. Totos transexuales fotoz transexuales galería de fotos colectivo de lesbianas gays transexuales y bisexuales de madrid > secciones reunión Área transexual cogam 25 noviembre 2006 fotos transexualez fotos trnasexuales. Etiquetas: pollachicasvideostransexualesdesnudassexoencorridastransexsualesde gratisfollandogratistrans comconfotospollastransexualtravestis preciosas travestis fotos de travestis gratis chat en vivo desde www.blogtravesti.org videos de travestis te permite descargar o ver videos de travestis online gratis aquí los limks van a donde indican sin engaños fotos y videos gratis fotos transsexuales. Fotos t5ansexuales www.blogdetransexuales.com foto porno transexual rubia y cachonda galerias de fotos y videos de las transexuales mas calientes de la web - videos x sms - travestis follando y mamando la polla - si te gustan las fiestas travestis follando transexuales webcams travestis webcams porno. Fotos transexuales: blogs photos videos and more on technorati fotos traneexuales fotos transexales www.travestiscachondas.com transexuales-travestis: transexuales y travestis en accion en fotos y videos para que puedas transexulaes galerias de transexuales fotos transexuales. Fotos transrxuales fotos trransexuales fotos trnsexuales fotos rtansexuales sexo transexual gratis fotos transexuales sexo con transexuales en vivo y videos de transexuales gratis.
Title:
Pharmaceutic formulation for the treatment of alcoholism
Document Type and Number:
United States Patent 5519017

Abstract:
Galanthamine and the pharmaceutically suitable acid addition salts thereof can be used for the treatment of alcoholism; these compounds are released from adequate pharmaceutic formulations which are administered, e.g., orally, transdermally, or otherwise parenterally, in a continuous and controlled manner.
Inventors:
Opitz, Klaus (Munster, DE)
Application Number:
08/238550
Publication Date:
05/21/1996
Filing Date:
05/05/1994
View Patent Images:
Images are available in PDF form when logged in. To view PDFs, Login  or  Create Account (Free!)
Referenced by:
View patents that cite this patent
Export Citation:
Click for automatic bibliography generation
Assignee:
LTS Lohmann Therapie-Systeme GmbH + Co. KG (Neuwied, DE)
Hefa-Frenon Arzneimittel GmbH & Co. KG (Werne, DE)
Primary Class:
514/215
Other Classes:
514/811
International Classes:
A61K9/70; A61K31/55; A61K31/55
Field of Search:
514/215, 514/811
US Patent References:
4663318Method of treating Alzheimer's diseaseMay, 1987Davis514/252
4761429Enkephalinase and endorphinase inhibitors as anti-craving compositionsAugust, 1988Blum et al.514/561
4777173Method for treatment of alcohol abuseOctober, 1988Shrotryia et al.514/561
4954504N.sub.9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activitySeptember, 1990Chen et al.514/265
5152994Rapid method for interrupting or attenuating poly-drug dependency syndromesOctober, 1992Lotsof424/436
Other References:
Bickel, U., Thomsen, T., Weber, W., Fischer, J. P., Bachus, R., Nitz, M., Kewitz, H.: "Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition." Clin. Pharmacol. Ther., 50: 420-28 (1991).
Cozanitis, D. A., Toivakka, E.: "Treatment of respiratory depression with the anticholinesterase drug galanthamine hydrobromide." Aneasthesia, 29: 581-84 (1974).
Cozanitis, D. A.: "Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of Scopolamine (Hyoscine)." Anaesthesist, 26: 649-50 (1977).
Cozanitis, D. A., van de Pol, F., van Wezel, H., Crul, J. F.: "Antagonistic activity of galanthamine on constant infusion of pancuronium in rats." Experientia, 37: 1326-27 (1981).
Cozanitis, D. A., Friedmann, T., Furst, S.: "Study of the analgesic effects of Galanthamine, a Cholinesterase Inhibitor." Archives Intern. de Pharmacodynamie et de Therapie, 266: 229-38 (1983).
Foitzik, H., Lawin, P.: "Klinische Erfahrungen mit Galanthamin (Nivalin) als Antidot von Pancuronium." Z. prakt. Anasth., 7: 203-7 (1972).
Gopel, W., Bertram, W.: "Erfahrungen mit Nivalin in der neurologischen Therapie." Psychiat. Neurol. med. Psychol., 23: 712-18 (1971).
Mayrhofer, O.: "Erfahrungen mit Galanthamin (Nivalin als Antagonist der Relaxantien vom Curaretyp." Bull. schweiz. Akad. med. Wiss., 23: 48-52 (1967).
Mihailova, D., Yamboliev, I., Zhivkova, Z., Tencheva, J., Jovovich, V.: "Pharmacokinetics of Galanthamine Hydrobromide after single subcutaneous and oral dosage in humans." Pharmacology, 39: 50-58 (1989).
Naranjo, C. A., Sellers, E. M. (Ed.): "Drug treatments for alcoholism: The need for innovation." in: Research Advances in New Psychoparm. Treatments for Alcoholism, 1-9 Elsevier Science Publishers B.V. (1985).
Paskov, D. S.: "Galanthamine." in: New Neuromuscular Blocking Agents, 31:653-72 Springer-Verlag Berlin, Heidelberg, New York, Tokyo (Ed.) (1986).
Snorrason, E., Stefansson, J. G.: "Galanthamine hydrobromide in mania." Lancet, 337: 557 (1991).
Stojek, A., Napierala, K.: "Physostigmine in eyedrops decreases craving for alcohol in early with withdrawal treated with carbamazepine." Materia Medica Polona, 4: 249-54 (1986).
Tanahashi, T., Poulev, a., Zenk, M. H.: "Radioimmunoassay for the quantitative determination of Galanthamine." Planta Medica, 56: 77-81 (1990).
Tencheva, J., Yamboliev, I., Zhivkova, Z.: "Reversed-phase liquid chromatography for the determination of galanthamine and its metabolites in human plasma and urine." Journal of Chromatography, 421: 396-400 (1987).
Thomsen, T., Bickel, U., Fischer, J. P., Kewitz, H.: "Stereoselectivity of cholinesterase inhibition by galanthamine and Eur. J. Clin. Pharmacol. and tolerance in humans" 39: 603-5 (1990).
Thomsen, T., Zendeh, B., Fischer, J. P., Kewitz, H.: "In vitro effects of various cholinesterase inhibitors on acetyl-- and butyrylchloinesterase of healthy volunteers." Biochemical Pharmacology, 41: 139-41 (1991).
Thomsen, T., Kaden, B. Fischer, J. P., Bickel, U., Barz, H., Gusztony, G., Cervos-Navarro, J. Kewitz, H.: "Inhibition of Acetylcholinesterase activity in human brain tissue and erythrocytes by Galanthamine, Physostigmine and Tacrine." Eur. J. Clin. Chem. Clin. Biochem., 29: 487-92 (1991).
Thomsen, T., Kewitz, H.: "Selective inhibition of human acetylcholinsterase by Galanthamine in vitro and in vivo." Life Sciences, 46: 1553-58 (1990).
Vlahov, R., Krikorian, D., Spassov, G., Chinova, M., Vlahov, I., Parushev, S., Snatzke, G., Ernst, L., Kieslich, K., Abraham, W.-R., Sheldrick, W. S.: "Synthesis of Galanthamine and related alkaloids-New approaches." Tetrahedron, 45: 3329-45 (1989).
J. Ruprecht et al: "The involvement of the central cholinergic and endorphinergic systems in the nitrous oxide withdrawal syndrome in mice." Anesthesiology, V. 58, No. 6, 1983, pp. 524-526.
Haboubi, N. A. et al, Ann. Clin. Biochem. 23(4): 458-62, 1986.
Hsu, L. L. et al., Alcohol Clin Exp Res 7(3); 249-55, 1983.
Stojek, A. et al., BR J Addict 82(8): 927-30; 1907.
Daunderer, M., Fortschr Med 101 (17); 778-80, 1983.
Power, J. S. et al.; J. Clin. Pharmacol. 21(1); 57-60, 1981.
Riley, E. P. et al., Alcohol Clin Exp Res 10(1); 50-53, 1986.
Rupreht, J. et al., Anesthesiology, 58(6), pp. 524-526, 1983.
Goodman Gilman et al., The Pharmacological Basis of Therapeutics (6th Ed.) Macmillan Publ. Co., N.Y., 1980, pp. 552-553.
Primary Examiner:
Cintins, Marianne M.
Assistant Examiner:
Moezie M.
Attorney, Agent or Firm:
Sprung Horn Kramer & Woods
Parent Case Data:
Claims:
I claim:

1. A method of reducing the desire for alcohol in a patient suffering from alcoholism which comprises administering to such patient an amount effective to reduce the desire for alcohol of a material comprising galanthamine (4a, 5, 9, 10, 11, 12-hexahydro-3-methoxy-11-methyl-6H-benzofuro [3a, 3, 2-ef][2] benzazepine-6-ol) of the formula ##STR2## or a pharmaceutically acceptable acid addition salt thereof.

2. The method according to claim 1, wherein the material is administered orally.

3. The method according to claim 1, wherein the material is administered parenterally.

4. The method according to claim 1, wherein the material is administered transdermally.

5. The method according to claim 1, wherein the material is dissolved or dispersed in a liquid.

6. The method according to claim 4, wherein the material is in the form of an applicator comprising

7. The method according to claim 6, wherein the applicator also contains a membrane controlling the release of the active substance.

8. The method according to claim 6, wherein the applicator contains a removable protective layer.

9. The method according to claim 7, wherein the applicator contains a removable protective layer.

Description:





<- Previous Patent (Aryl group- or aroma...)   |   Next Patent (Substituted phenols ...) ->





index
peliculas de lesbianas mundo pornostar relatos de sexo fuerte mujeres tetonas otos de sexo hardcore chicas tetonas amateur cońo asiatica gratis otos de sexo hardcore famosas en la playa amateur cońo